A new topical panthenol-containing emollient: Results from two randomized controlled studies assessing its skin moisturization and barrier restoration potential, and the effect on skin microflora.

Erscheingsdatum 
August 2016
Autoren 
H. Stettler, P. Kurka, N. Lunau, C. Manger, A. Böhling, S. Bielfeldt, KP Wilhelm, S. Dähnhardt-Pfeiffer, D. Dähnhardt, F. H. H. Brill, H. Lenz
Bibliografische Daten 
The Journal of dermatological treatment, 2016 Aug 2:1-8. [Epub ahead of print], PMID: 27425824, DOI: 10.1080/09546634.2016.1214235
Abstract 

PURPOSE:

Two randomized, intra-individual comparison studies were performed in healthy subjects to evaluate the skin moisturization and barrier restoration potential of a new topical panthenol-containing emollient (NTP-CE) (Study 1), and its effect on skin microflora (Study 2).

METHODS:

In Study 1 (N = 23), two skin areas, one challenged with 0.5% sodium dodecyl sulfate (SDS) solution and one unchallenged, were treated with NTP-CE for 3 weeks. Transepidermal water loss (TEWL), skin hydration, and intercellular lipid lamellae (ICLL) organization were measured at regular intervals during the study. In Study 2 (N = 20), quantitative bacterial cultures were obtained over 6 h from a skin area undergoing wash stress with 10% SDS with subsequent single application of NTP-CE.

RESULTS:

In Study 1, mean AUC for TEWL reduction from baseline was more pronounced with NTP-CE compared with control (-168.36 vs. -123.38 g/m2/h, p = 0.023). NTP-CE use was also associated with statistically significant improvements in stratum corneum hydration and an increase in mean ICLL length from baseline (day 22: 120.61 vs. 35.85 nm/1000 nm2, p < 0.001). In Study 2, NTP-CE use had no negative impact on bacterial viability.

CONCLUSIONS:

NTP-CE use has favorable and lasting effects on barrier function and repair as well as skin hydration without negatively influencing bacterial viability.

KEYWORDS:

Emollient; microbiome; moisturization; panthenol; randomized controlled study; repair; skin; skin barrier; topical