Virucidal activity of WHO-recommended formulations against enveloped viruses including Zika, Ebola and emerging Coronaviruses

Februar 2017
Online ISSN 1537-6613 / Print ISSN 0022-1899
Anindya Siddharta, Stephanie Pfaender, Nathalie Jane Vielle, Ronald Dijkman, Martina Friesland, Britta Becker, Jaewon Yang, Michael Engelmann, Daniel Todt, Marc P. Windisch, Florian H. Brill, Joerg Steinmann, Jochen Steinmann, Stephan Becker, Marco P. Alves, Thomas Pietschmann, Markus Eickmann, Volker Thiel, Eike Steinmann
Bibliografische Daten 
The Journal of Infectious Diseases, J Infect Dis (2017) jix046, PMID: 28158346, DOI: 10.1093/infdis/jix046 [Epub ahead of print], Published: 01 February 2017

The World Health Organization (WHO) published two alcohol-based formulations to be used in healthcare settings and outbreak-associated infections, but inactivation efficacies of these products have not been determined against (re-) emerging viruses. In this study, we evaluated the virucidal activity of these WHO products in a comparative analysis. Zika virus (ZIKV), Ebola virus (EBOV), Severe Acute Respiratory Syndrome coronavirus (SARS-CoV), Middle East Respiratory Syndrome coronavirus (MERS-CoV) as (re-) emerging viral pathogens and other enveloped viruses could be efficiently inactivated by both WHO formulations implicating their use in healthcare systems and viral outbreak situations.